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Timing Is Everything: How Circadian Rhythms Shape β-Cell Function
We often think of pancreatic β-cells as simple glucose sensors that detect glucose and release insulin in response. But in reality, they behave more like highly trained performers following a daily script. That script is written by the body’s internal clock and is known as the circadian rhythm. Circadian rhythms are 24-hour cycles controlled by specialized...
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Broadcasting 06-26-2026
Upcoming Free Webinar: Preventing Type 1 Diabetes
We’re excited to invite you to our second webinar, taking place on June 26 at 12:00 PM (Eastern Time). Join internationally recognized expert Dr. Bruce Perkins (University of Toronto) for an insightful presentation on Type 1 diabetes. Dr. Perkins will explore how the condition can be predicted through screening—including among family members, individuals with related...
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How Do CFTR Modulator Therapies Help Insulin-Producing Cells in Cystic Fibrosis?
Cystic fibrosis (CF) is a genetic disease caused by mutations in a protein called CFTR. This protein controls the movement of salt and water into and out of cells throughout the body. The protein does not work properly in people with cystic fibrosis. Although this typically causes serious lung disease, the protein is also involved...
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How Stem Cells Are Rewriting the Cure for Type 1 Diabetes
Type 1 diabetes develops when the body’s immune system mistakenly attacks its own beta cells – the cells in the pancreas that produce insulin. This means that any cure requires scientists to solve two problems. First, finding a reliable source of healthy beta cells so that they can be transplanted into an affected person. Second,...
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Beyond Insulin: How Other Cells in the Pancreas Contribute to Diabetes
Research on diabetes has often focused on insulin-producing beta cells, even though they make up only about 0.5–2% of all the cells in the pancreas. Recently, scientists have started to look beyond beta cells and consider how the entire pancreas affects the development of diabetes. Other hormone-producing cells in the pancreas also change during diabetes....
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Where Do Transplanted Beta Cells Go In The Body?
Islet transplantation is an emerging therapy that aims to restore insulin-producing beta cells in people with type 1 diabetes (T1D). But an important question is: where in the body should these cells be placed? Transplantation sites can be broadly divided into two categories: intravascular (through blood vessels) and extravascular (into tissues outside the bloodstream). In...