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Will My Children Inherit My Diabetes?
Diabetes is very common. Although its frequency varies with ancestry, an average of one of every nine or ten Canadians has diabetes. More than 90% of these people have type 2 diabetes, while less than 10% have type 1 diabetes. There is no question that genetics plays a role in the development of both types...
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Off-Label Use of Drugs Like Semaglutide and Tirzepatide in People With Type 1 Diabetes
The drugs semaglutide (marketed as Ozempic and Wegovy) and tirzepatide (marketed as Mounjaro and Zepbound) are widely used to treat people with type 2 diabetes. Many large, well-done research studies of thousands of people have clearly shown that these drugs can improve glucose control, reduce the need for other glucose lowering drugs, and promote weight...
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Webinar Recap: Preventing Type 1 Diabetes
For a long time, doctors had to wait until someone got really sick before they could diagnose them with Type 1 Diabetes (T1D). By that time, the body had mostly stopped making insulin, and the patient had to start taking insulin shots right away. But today, we are entering a brand-new era. Scientists have figured...
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How Stem Cells Are Rewriting the Cure for Type 1 Diabetes
Type 1 diabetes develops when the body’s immune system mistakenly attacks its own beta cells – the cells in the pancreas that produce insulin. This means that any cure requires scientists to solve two problems. First, finding a reliable source of healthy beta cells so that they can be transplanted into an affected person. Second,...
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Where Do Transplanted Beta Cells Go In The Body?
Islet transplantation is an emerging therapy that aims to restore insulin-producing beta cells in people with type 1 diabetes (T1D). But an important question is: where in the body should these cells be placed? Transplantation sites can be broadly divided into two categories: intravascular (through blood vessels) and extravascular (into tissues outside the bloodstream). In...
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Why Is It So Hard To Keep Transplanted Beta Cells Alive?
Why are beta cells transplanted? Insulin-producing beta cells in the pancreas are critical for helping to keep blood sugar levels in a healthy range. Type I diabetes develops when these cells, found in cell clusters called islets, are attacked and destroyed by a person’s own immune system. Clinical trials have shown that it is possible...