The Basics

A collection of articles on topics related to diabetes

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Aging and Diabetes – How Do We Slow It Down?
Diabetes Care
The Basics

Aging and Diabetes – How Do We Slow It Down?

Many articles and videos on this platform discuss the long-term health effects of diabetes. The bottom-line is that people with diabetes have a higher chance of getting a wide variety of serious health problems over time. The most serious ones are blindness, kidney failure, heart attacks, heart failure, strokes, amputations, dementia, cancers, and some infections....

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Beyond Insulin: How Other Cells in the Pancreas Contribute to Diabetes
The Basics

Beyond Insulin: How Other Cells in the Pancreas Contribute to Diabetes

Research on diabetes has often focused on insulin-producing beta cells, even though they make up only about 0.5–2% of all the cells in the pancreas. Recently, scientists have started to look beyond beta cells and consider how the entire pancreas affects the development of diabetes. Other hormone-producing cells in the pancreas also change during diabetes....

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Are all β-cells destroyed in T1D?
The Basics
Type 1 Diabetes

Are all β-cells destroyed in T1D?

The pancreas contains clusters of cells called islets. Insulin is produced by one of these cell types – the β-cell (or beta cell). As discussed in many other blogs, insulin is the only hormone that lowers blood glucose levels. In people with type 1 diabetes (T1D), the body’s immune system mistakenly attacks and destroys these...

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Are Beta Cells Dead in Diabetes, or Are They Just Hiding?
The Basics
Type 1 Diabetes
Type 2 Diabetes

Are Beta Cells Dead in Diabetes, or Are They Just Hiding?

People with diabetes do not make enough insulin to maintain normal glucose levels. Reasons for this are not obvious and remain the subject of much research. Because insulin is made by the beta cells of the pancreas, it was initially believed that beta cell death was the cause of reduced insulin production in both type...

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Understanding the Different Types of Endocrine Cells in the Pancreatic Islets
The Basics

Understanding the Different Types of Endocrine Cells in the Pancreatic Islets

The pancreas is an organ in the centre of the abdomen. It is made up of two compartments. These are the exocrine compartment, which contain cells that secrete enzymes into the gut to break down the food we eat, and the endocrine compartment, which contains cells that make several hormones that are secreted into the...

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Beta Cell Mitochondrial Dysfunction in Type 2 Diabetes
The Basics
Type 2 Diabetes

Beta Cell Mitochondrial Dysfunction in Type 2 Diabetes

Pancreatic beta cells make insulin, a hormone that helps control blood sugar levels in the body. Type 2 diabetes (T2D) is a metabolic disease in which these beta cells do not work properly and cannot release enough insulin to keep blood sugar at a healthy level. To release insulin, beta cells need energy. This energy...

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